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As in the case of the transgenic mice developed by Jones et al.,MDM2 overexpression would be predicted to lower WT p53 levels in mousemammary epithelial cells. This diagram shows the location and migrationpathways ofepidermal stem cells that reside in the follicular bulge. The N-terminal region of p53 is a disordered, natively unfoldedregion  containing the acidic TAD (transactivation domain), which is a bindingsite for some of the p53 interacting proteins such as the transcriptional machineryproteins , and MDM2 . (2000) Prospective validationof consensus criteria for the diagnosis of dementia with Lewybodies. Five strate-gies that heighten nurses’ awareness of spirituality to impact client care Five strate-gies that heighten nurses’ awareness of spirituality to impact client care.
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